Analysis of the association of the G-7A polymorphism of the matrix Gla protein gene with ischemic atherothrombotic stroke in humans with its different risk factors

Abstract

The G-7A polymorphism (rs1800801) of the matrix Gla protein (MGP) gene was determined in 170 patients with ischemic atherothrombotic stroke (IATS) and 124 control persons. It was found that the distribution of the major allele homozygotes, heterozygotes, and minor allele homozygotes was 35.9, 48.8, and 15.3% in patients with IATS (in the control, 43.5, 50.0, and 6.5%; P = 0.051 by the χ2 test). Significant differences in the distribution of genotypes were revealed only in women (P = 0.022). The odds ratio (OR) for minor allele homozygotes (A/A) vs. major allele carriers (G/A + G/G) was 2.618 (P = 0.023), while in women it was equal to 6.645 (P = 0.015). In patients with the A/A genotype, the values of the blood coagulation parameters (prothrombin time) indicated increased their predisposition to hypercoagulability. The results obtained prove that the A/A variant of the MGP gene is associated with an increased risk of IATS in females of the Ukrainian population and may be related to blood hypercoagulability and formation of thrombi.