Analysis of the association of HLA-A, HLA-B, HLA-DRB1, HLA-DQ alleles with leprosy

Abstract

Objective To explore the association of HLA-A,HLA-B,HLA-DRB1,HLA-DQ alleles with leprosy in population of Jinan.Methods PCR-SSP was used to analyse the type of HLA-A,HLA-B,HLA-DRB1 and HLA-DQ alleles in 40 patients with leprosy and 20 healthy controls.SPSS 11.5 software package was used to analyze the data.Results The allele frequencies of HLA-B * 13 (x2 =7.067,P =0.008)and DQ * 02 (x2 =4.156,P =0.041 ) were lower in leprosy patients than those in healthy controls( P ＜ 0.05 ).The allele frequencies of HLA-B * 13 (x2 =7.159,P =0.007 )was lower than that in controls and the frequencies of HLA- DRB 1 * 15 (x2 =4.073,P =0.044) was higher in LL leprosy patients ( P ＜ 0.05 ).The allele frequencies of HLA-B * 40 ( P =0.037 ) and DQ * 05 (x2 =5.147,P =0.023 ) were higher in TT leprosy patients (P＜0.05).Conclusion HLA-B * 13 and DQ *02 possibly play protective roles in leprosy patients.B * 13 has also protective roles and DRB1 * 15 was a susceptibility gene in LL leprosy patients.B *40,DQ *05 may be susceptibility genes in TT leprosy patients. Key words: Leprosy; HLA-A、B 、DRB1 、DQ; Polymorphism