Abstract
Genomic instability comprises one of the main events of carcinogenesis and tumor progression. The objective of this study was to analyze the immunoreactivity of DNA nucleotide excision repair proteins, THIIF and XPF, in oral tongue squamous cell carcinoma (OTSCC) and investigate possible associations with clinical parameters and outcome. Fifty cases of OTSCC were stained by immunohistochemistry and the expression of THIIF and XPF proteins were measured by semi-quantitative analysis. Clinical variables of interest were collected from patients' charts and statistical tests were performed (Chi-square and Fisher's exact tests, significance of 5%) to investigate associations between these data and proteins immunoexpression. High expression of the studied proteins in parenchymal cells was observed; however, significant association of proteins immunoexpression with TNM staging, locoregional recurrence, and death was not identified. The results of this experiment suggest that TFIIH and XPF proteins participate in the tumorigenesis process; however, their immunoexpression cannot be used as an independent prognostic indicator for OTSCC.
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