Analysis of the association between helicobacter pylori infection and laryngeal lesions

Abstract

Objective:To investigate the relationship between Helicobacter pylori（H.pylori） infection and laryngeal lesions. Method:204 patients with laryngeal lesions were arranged into laryngeal lesions group, and 150 healthy persons who were willing to accept the electronic fiber gastroscopy examination in the same period were selected as control group. The positive rate of H.pylori infection in the two groups was observed and the association between H.pylori infection status and clinical characteristics in patients with laryngeal diseases was analyzed. Result:The positive rate of H.pylori infection in laryngeal lesion group and control group were 56.86% and 47.33%（χ²=3.150, P=0.076）, respectively. Among the patients with laryngeal lesion, the positive detection rate of H.pylori was not associated with age, gender, or gastric disease history. The positive rate of H.pylori infection in benign lesions, precancerous lesions and laryngeal malignant lesions were 53.70%, 55.56% and 75.00%, respectively. The difference of positive rate of H.pylori infection in laryngeal malignant lesions was significantly higher than other kinds of lesions（χ²=6.338, P=0.012）. Among laryngeal precancerous lesions and laryngeal malignant lesions patients, the appearance rate of gastrointestinal lesions were significantly higher in the patients with positive H.pylori infection than those without H.pylori infection（P<0.05）. Conclusion:H.pylori infection was positively related to the severity of laryngeal lesions and highly positively related to laryngeal malignant lesions.