Abstract
Relevance. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivity reactions that can be induced by drugs and are particularly severe in children.Objective. To study the structure of antibacterial drugs (ABs) involved in the development of SJS and TEN in pediatric populations.Methods. Retrospective pharmacoepidemiologic study of spontaneous reports (SRs) entered into the Russian National Pharmacovigilance database during the period 01.04.2019 – 31.12.2023.Results. The majority of suspected drugs were β-lactams (76.0%), with penicillin accounting for 47.4% and cephalosporins — for 52.6%. Amphenicols (12.0%), macrolides (8.0%), and fluoroquinolones (4.0%) were less frequently reported.Conclusion. The most common group of ABs that induce SJS and TEN in children is the group of β-lactam antibiotics.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
