Analysis of specificity IgE detection results in patients with bronchial asthma in Xi′an

Abstract

Objective To investigate the allergens characteristics with bronchial asthma at different age groups in Xi′an area, to find athogenic factors of bronchial asthma and to provide a basis for the environment control and immunotherapy. Methods From October 2016 to January 2017, 140 cases of asthma were diagnosed in the respiratory medicine and outpatient department of respiratory of the second affiliated hospital of Xi′an Jiaotong university.They were divided into adult group and children group according to age.Serum allergens sIgE and all IgE in 140 asthma cases in the children group and the adult group were detected by using western blotting with pathogenic factors of bronchial asthma, and the results were retrospectively analyzed. Results In 140 cases, positive rate of total IgE in the children group and the adult group was 53.4% and 60.9% respectively, and it showed no significant differences (P>0.05). In inhalant allergens, sIgE positive rate in 58 cases of the children group was main in house dust, cat/dog dander, which accounted for 44.78% and 27.59% respectively; sIgE positive rate in 82 cases of the adult group was main in dermatophagoides pteronyssinus, house dust, which accounted for 63.41% and 48.78% respectively.In ingested allergens, sIgE positive rate in 58 cases of the children group was main in crab fish, wheat and beef/mutton, which accounted for 18.97%, 13.79% and 12.07% respectively; sIgE positive rate in 82 cases of the adult group was main in crab fish, egg and cashew/peanut, which accounted for 30.49%, 30.49% and 26.83% respectively.In inhalant allergens, sIgE positive rate of tree combination and dermatophagoides pteronyssinus was in adult group was higher than in the children group, which was 31.71%/8.62% and 63.41%/10.34%.The difference was statistically significant (P<0.05). In food allergens, sIgE positive rate of egg and cashew/peanut in adult group was higher than in the children group, which was 30.49%/10.34% and 26.83%/6.89%.The difference was statistically significant difference (P<0.05). Conclusions There was no statistically significant difference in total IgE and sIgE between adult group and the children group.But in the two groups, there was difference in the types of allergens in inhalant and food allergens, providing scientific basis for the clinical diagnosis and treatment of asthma among different age groups. Key words: Asthma; Immunoglobulin; Allergen