Abstract
Background: At present, the spatial studies of liver cancer are too large for observation, or lack systematic spatial epidemics and statistical analyses, so it is difficult to put forward more targeted regional prevention and control measures. This study takes the natural village of Longkou City, Shandong as a small regional research unit, to systematically analyze the spatial structure and spatial heterogeneity of liver cancer in the small region (village as a unit), and provide a scientific basis for the development of regional prevention and control measures for more targeted liver cancer and its related diseases. Methods: Based on the database of the integrated management information system for chronic diseases and death monitoring in Shandong Center for Disease Control and Prevention, the spatial epidemiology and spatial statistics methods were combined in the framework of geographic information system (GIS). Results: The results of spatial distribution showed that there was obvious spatial heterogeneity on liver cancer in Longkou City, and there were many high incidence and high death areas scattered in the distribution. The spatial scanning and space-time scanning results of liver cancer showed that there were relatively fixed high incidence and high death villages in the small area of Longkou City. Conclusion: This study suggests that the liver cancer in Longkou City has a local geographic risk factor, which may have obvious high incidence area, and time factors have a certain influence on the space area of liver cancer. It is necessary to further carry out the geographical weight regression and risk factors analysis, and expand the study model.
Highlights
With the application of geographic information system (GIS) in the research of chronic diseases, the studies on the spatial distribution of liver cancer have been published
The results show that the cumulative incidence of liver cancer has spatial autocorrelation (Moran's I= 0.0486, P=0.031), indicating the accumulation of liver cancer in Longkou City takes on positive spatial correlation, and there may exist high incidence areas
The spatial distribution of liver cancer in Longkou City shows that there is obvious spatial heterogeneity, that is, the spatial aggregation and randomness coexist, with many high incidence and high death areas scattered in the distribution, and the whole city exists a number of high incidence "focal points", suggesting a local geographic risk factor
Summary
With the application of GIS in the research of chronic diseases, the studies on the spatial distribution of liver cancer have been published. Weng Min et al took street as the research unit, using geographically weighted regression to quantitatively analyze the spatial relationship between liver cancer incidence and social deprivation [5] These studies, either are too large for observation in scale, or lack systematic spatial epidemics and statistical analysis, so it is still difficult to put forward more targeted regional prevention and control measures. This study takes the natural village of Longkou City, Shandong as a small regional research unit, to systematically analyze the spatial structure and spatial heterogeneity of liver cancer in the small region (village as a unit), and provide a scientific basis for the development of regional prevention and control measures for more targeted liver cancer and its related diseases. It is necessary to further carry out the geographical weight regression and risk factors analysis, and expand the study model
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