Abstract
Signaling by NO/cGMP relaxes various smooth muscles, modulating thereby vascular tone and gastrointestinal motility. An important signaling pathway of cGMPdependent protein kinase type I (cGKI)-dependent relaxation is mediated by IRAG (IP3 Receptor Associated cGKI substrate) which is highly expressed in smooth muscle tissues. In order to elucidate the physiological role of IRAG we generated IRAG knockout mice by targeted deletion of exon 3.
Highlights
Matthias M Desch*1, Katja Sigl2, Beate Spiessberger2, Dominik Bernhard2, Angela Jochim2, Jörg W Wegener2, Franz Hofmann2 and Jens Schlossmann1,2
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
An important signaling pathway of cGMPdependent protein kinase type I-dependent relaxation is mediated by IRAG (IP3 Receptor Associated cGKI substrate) which is highly expressed in smooth muscle tissues
Summary
Matthias M Desch*1, Katja Sigl2, Beate Spiessberger2, Dominik Bernhard2, Angela Jochim2, Jörg W Wegener2, Franz Hofmann2 and Jens Schlossmann1,2. Analysis of smooth muscle function in IRAG knockout mice
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