Analysis of single nucleotide polymorphism rs415430 in the WNT3 gene in Parkinson’s disease in Russian population

Abstract

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease that arises as a result of the destruction of dopaminergic neurons. Reasons for the development of PD are not completely clarified and, at present, a number of genes involved in the development of both familial and sporadic PD forms have been detected. According to recent data from genome-wide association studies, single nucleotide polymorphisms (SNPs) in these genes (including the MAPT locus) can play a significant role in the development of PD. In connection with the above, we analyzed the distribution of genotype frequencies of SNP rs415430 in WNT3 gene in Russian patients with sporadic PD and in Russian population controls (OR = 0.84, Confidence Interval (95% CI) 0.58–1.23, p = 0.39). We conclude that the WNT3 gene rs415430 SNP does not influence the risk of the development of PD in the Russian population.