Analysis of Simple Half-Shared Transimpedance Amplifier for Picoampere Biosensor Measurements.

Abstract

High-throughput recordings of small current are becoming more common in biosensor applications, including in vivo dopamine measurements, single-cell electrophysiology, photoplethysmography, pulse oximetry, and nanopore recordings. Thus, a highly scalable transimpedance amplifier design is in demand. Half-shared amplifier design is one way to improve the scalability by sharing the non-inverting side of the operational amplifier design for many inverting halves. This method reduces silicon area and power by nearly half compared to using independent operational amplifiers. In this paper, we analyze the scalability of a simple half-shared amplifier structure while investigating the tradeoff of increasing the number of inverting half amplifiers sharing a single non-inverting half. A transimpedance amplifier is designed using the half-shared structure to minimize the size per amplifier. The transimpedance amplifier is based on a current integration of a capacitor. The noise analysis of the integration amplifier is a challenging task because it does not reach a steady-state, thus, being a non-stationary circuit. For frequency analysis, a conversion method is discussed to estimate the noise characteristic in the simulation. The array design of 1024 transimpedance amplifiers is fabricated using a standard 0.35 μm process and is tested to confirm the validity of above analysis. The amplifier array exhibits high linearity in transimpedance gain (7.00 mV/pA for high gain and 0.86 mV/pA for low gain), low mismatch of 1.65 mV across the entire 1024 amplifier array, and extremely low noise. The technique will be crucial in enabling the fabrication of larger arrays to enable higher throughput measurement tools for biosensor applications.