Abstract
Tetracyclines are broad spectrum antibiotics and one type of various their compounds—chlortetracycline has been successfully used for our cytogenetic studies. We have selected for these studies the chromosomal assay because it is wellknown cytogenetic biomarker, which has been used to assess DNA damage at the chromosomal level. We analyzed the chromosomal aberrations and mitotic index in peripheral lymphocytes of sheep exposed by chlortetracycline chloride in pure tap water. To the food of the experimental group of animals (à n = 6) were added also 0.35 gof preparation Aureovit12 C80 plv. a. u. v. per kg b. w. and day (i.e. 168 mg of chlortetracycline hydrochloride/kg b. w.) daily in food. The frequencies of aberrant cells (ABC) in the experimental and control groups of sheep were stated to differ significantly (P = 0.001). In experimental group, chromatid breaks were the dominant type of chromosomal aberrations. No statistical differences in mitotic index values were found in the both groups (P > 0.05). Increased frequencies of chromosome aberrations in peripheral lymphocytes of sheep exposed by chlortetracycline in food, suggested a potential hazard which needs the attention from the viewpoint of human and animal health. This knowledge is useful for all, for the human and veterinary medicine, as well as for the aquaculture. Many of these chlortetracycline substances for their environmental persistence and chemical unstability are present in the environment for various periods, and as a result, they are responsible for several effects on human and animal health through food chain.
Highlights
Tetracyclines (TCs) are broad spectrum antibiotics that have been successfully used worldwide in human and veterinary medicine and in aquaculture [1,2,3,4]
Chromatid breaks were the dominant type of chromosomal aberrations
Increased frequencies of chromosome aberrations in peripheral lymphocytes of sheep exposed by chlortetracycline in food, suggested a potential hazard which needs the attention from the viewpoint of human and animal health
Summary
Tetracyclines (TCs) are broad spectrum antibiotics that have been successfully used worldwide in human and veterinary medicine (mainly for medical therapy of diseases) and in aquaculture [1,2,3,4]. Their effect may be significantly limited [5]. Many of these substances for their environmental persistence and chemical unstability, are present in the environment for long period, and as a result they are responsible for several effects on human and animal health through food chain [6]. HCl (TC) have been studied in human fibroblast experiments and human peripheral lymphocytes [10,11,12]
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