Analysis of serum 25-Hydroxyvitamin D level in keloid patients

Abstract

Background: Keloid is solid fibrous tissue tumors that occur due to an imbalance between deposition and degradation of extracellular matrix components, especially collagen. Vitamin D is known to have a beneficial role in slowing the progression of tissue fibrosis and proven to play an important role in the synthesis and degradation of collagen and acts as an anti-inflammatory mediator.Aim: To determine the difference between serum 25-hydroxyvitamin D level in keloid patients and controls.Method: This is a cross-sectional analytic study involving 60 subjects consist of 30 keloid patients and 30 controls. Keloid patients were diagnosed by history and clinical examinations, and we conducted blood sampling and measurement of serum 25-hydroxyvitamin D level to the patients and controls.Results: The mean of serum 25-hydroxyvitamin D level in keloid patients (16.92 ± 5.96 ng/mL) was significantly lower than controls (23.57 ± 6.72 ng/mL), p=0.0001Conclusion: Serum 25-hydroxyvitamin D level in keloid patients was significantly lower than controls, serum 25-hydroxyvitamin D level in keloid patients was higher in the male group, aged 31-35 years group, duration of disease between 6-10 years group and positive family history.