Abstract
Background: Colorectal adenocarcinoma is a result of the malignant transformation of epithelial cells in the colonic mucosa caused by tumor-specific mutations and epigenetic aberrations. One of the recently identified epigenetic biomarkers is Septin 9 (SEPT9), whose aberrantly methylated circulating DNA sequence can be found in plasma samples and also in colonic biopsies is highly associated with the occurrence of colorectal cancer. Although the sensitivity of the Septin 9 methylation assay gives the possibility to be applied as an efficient screening method, its influence on the gene expression level in the colonic tissue still remains to be elucidated.
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