Analysis of Sentinel Lymph Node Biopsy on Clear Cell Sarcoma Treatment

Eurico Cleto Ribeiro De Campos,Marcus Rivabem Winheski,Renan Martins,Ricardo Poroski,Robson Menezes Leal,Marcos Gonçalves Adriano Júnior ,Diego Sanches ,Emanuela Benevides Poyer ,Marcela Santos Cavalcanti

doi:10.4236/jct.2020.1112068

Eurico Cleto Ribeiro De Campos, Marcus Rivabem Winheski + Show 7 more

Open Access

https://doi.org/10.4236/jct.2020.1112068

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Abstract

Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds to a less than 1% of all sarcomas and is a high degree neoplasm with propensity to disseminate to regional lymph nodes. Regional lymphadenectomies have a controversial impact on sarcomas treatment and survival, even though those patients have higher local recurrence and lower survival. So, sentinel lymph node biopsy must be one option for better regional staging to STS with higher propensity to lymph node commitment. The authors demonstrate two cases of CCS submitted to surgery through compartmental resection associated with the sentinel lymph node biopsy. A literature review about soft tissue sarcoma and lymph node sentinel biopsy is shown as an initial experience of two cases.

Highlights

Clear Cell Sarcoma (CCS) represents less than 1% of all sarcomas, which is characterized as a rare and aggressive neoplasm [1]
Clear Cell Sarcoma (CCS) is a rare soft tissue sarcoma that corresponds to a less than 1% of all sarcomas and is a high degree neoplasm with propensity to disseminate to regional lymph nodes
The regional lymph nodes are compromised in some extent between 2% to 7% of sarcomas, raising the risk of involvement according to the histological subtype, like: epithelioid, rhabdomyosarcoma, synovial, angiosarcoma and the clear cell sarcoma [6]-[16]

Summary

Introduction

Clear Cell Sarcoma (CCS) represents less than 1% of all sarcomas, which is characterized as a rare and aggressive neoplasm [1]. Like all the sarcoma tumors, in a great proportion, it tends to affect the extremities. Among the subtypes of soft-tissue sarcoma, CCS is highlighted as one of the tumors that remarkably reach the local lymph nodes very frequently, making it possible to obtain a number up to 40% of histologically positive lymph nodes [3]. The regional lymph nodes are compromised in some extent between 2% to 7% of sarcomas, raising the risk of involvement according to the histological subtype, like: epithelioid, rhabdomyosarcoma, synovial, angiosarcoma and the clear cell sarcoma [6]-[16]. The sentinel lymph node (SN) appears as a locoregional staging tool for sarcomas in a more accurate manner, allowing the more radical surgical treatment, appropriate in the search for a better locoregional control taxes and at a distance [7] [13]

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