Analysis of screening results of congenital hypothyroidism in neonates in Baoji City of Shaanxi Province in 2008-2013

Abstract

Objective To understand the control effect of iodine deficiency disorders (IDD) in Baoji City, and to provide necessary information for decision-making and adjustment of IDD intervention. Methods From November 2008 to October 2013, basic information of congenital hypothyroidism (CH) was collected in Child Health Hospital of Baoji City, including thyroid stimulating hormone (TSH), three total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4), free thyroxine (FT4), and descriptive analysis was conducted. In 2013, 12 counties of Baoji City were selected; each county was divided into east, west, south, north and center parts; 12 pregnant women were selected in each part, and a disposable urine sample (5 ml) was collected; in the east, west, south, north and center parts of Baoji City, 3 mothers whose children had been diagnosed neonatal CH (1 years after giving birth) were selected, and a disposable urine sample (5 ml) was collected. Urinary iodine was detected by arsenic cerium catalytic spectrophotometry (WS/T 107-2006). Results In 2008-2013, a total of 198 575 cases of neonatal were screened, of which 68 cases were diagnosed as neonatal CH, the detection rate was 0.34 per thousand; TSH > 5.0 mU/L was 9 937, the detection rate was 5.00%; TSH≥8.5 mU/L was 94. A total of 720 pregnant women were examined, the median of urinary iodine was 218.57 μg/L, 0.05). Conclusions In Baoji City, iodine nutritional status of pregnant women is good, and the detection rate of CH is lower than the national average level (0.49‰). The monitoring of urinary iodine of pregnant women should be strengthened in the future to eliminate the influence of iodine deficiency on neonates. Key words: Urine; Iodine; Incidence; Data collection