ANALYSIS OF SCIENTIFIC RESEARCH ON CLINICAL APPLICATIONS OF L-CARNITINE IN PEDIATRIC PRACTICE

Abstract

The L-carnitine molecule was discovered 115 years ago by two scientists, Prof. R. P. Krimber and Prof. V. S. Gulevich. In 1962, the role of carnitine as a carrier of long-chain fatty acids into the mitochondria through their internal, highly selective membrane was discovered. L-carnitine is a vital compound that plays a crucial role in fat metabolism and energy metabolism in the child's body. The purpose of the study is to analyze the literature data on the current features of the clinical and pharmacological substantiation of the use of L-carnitine in pediatric practice. The article discusses aspects of the use of L-carnitine in pediatric medicine. L-Carnitine, essential for fatty acid metabolism, is synthesized endogenously and obtained from dietary sources. Ninety-eight percent of it is accumulated in skeletal muscles. its critical role in primary deficiencies, such as systemic encephalomyopathies and isolated myopathies, is unequivocal. L-Carnitine modulates glucose metabolism and increases the activity of respiratory chain enzymes. In addition, it acts as an antioxidant, preventing oxidative damage and inhibiting apoptosis, a signal in response to oxidative stress. Studies show that L-carnitine may be beneficial for children with metabolic disorders, athletes, and other categories of patients. However, it is important to consider dosage, safety, and potential side effects. Thus, the accumulated clinical experience of L-carnitine use indicates various positive effects and allows us to consider it an effective preventive and therapeutic agent that can be used in the pediatric population. Its applications extend to scenarios requiring energy support during heightened mental, emotional, and physical stress, as an adjunct therapy for diverse somatic diseases, during post-illness rehabilitation, and for bolstering immune reserves.