Abstract
The relations between RNA sequences and secondary structures are investigated by exhaustive folding of allGC andAU sequences with chain lengths up to 30. The technique oftries is used for economic data storage and fast retrieval of information. The computed structural data are evaluated through exhaustive enumeration and used as an exact reference for testing analytical results derived from mathematical models and sampling based on statistical methods. Several new concepts of RNA sequence to secondary structure mappings are investigated, among them the structure ofneutral networks (being sets of RNA sequences folding into the same structure),percolation of sequence space by neutral networks, and the principle ofshape space covering. The data of exhaustive enumeration are compared to the analytical results of arandom graph model that reveals the generic properties of sequence to structure mappings based on some base pairing logic. The differences between the numerical and the analytical results are interpreted in terms of specific biophysical properties of RNA molecules.
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