Analysis of risk factors of nosocomial infection during induction therapy phase in children with newly diagnosed acute leukemia

Abstract

Objective To investigate the risk factors of nosocomial infection in children with newly diagnosed acute leukemia during induction therapy phase. Methods The clinical data of 150 children with newly diagnosed acute leukemia in Henan Children’s Hospital from October 2014 to June 2017 were retrospecivel analyzed. Pearson univariate analysis and Logistic regression analysis were used to determine the risk factors of nosocomial infection in induction stage of acute leukemia. Results The nosocomial infection rates at induction stage of acute lymphoblastic leukemia, acute promyelocytic leukemia and acute myeloid leukemia (non-M3) were significantly different (P 7 days and PICC catheterization were the risk factors for nosocomial infection. Conclusions The nosocomial infection rate of children with acute leukemia in induction stage is high. It is necessary to restrict or reduce personnel access, strictly implement hand hygiene system, and shorten hospitalization time and granulocyte deficiency time as far as possible to reduce incidence of nosocomial infection. Key words: Acute leukemia in children; New diagnosis; Nosocomial infection; Risk factors