Abstract
Objective To investigate the incidence and risk factors for postoperative nausea and vomiting (PONV) following neurosurgical anesthesia.Methods 7 843 patients undergoing elective neurosurgery were included in this study.Patients' perioperative informations were recorded.Univariate and multivariate logistic regression was used to analyze the risk factors for PONV.Results PONV developed in 1 176 patients within 3 h following neurosurgery and the incidence was 15％.The logistic regression analysis indicated that the risk factors for PONV included female sex,infratentorial craniotomy,longer duration of surgery and postoperative median to severe pain.5-HT3 receptor antagonists prophylaxis and total intravenous anesthesia (TIVA) were protective factors (P ＜ 0.05).Conclusions Female sex,infratentorial craniotomy,longer duration of surgery and postoperative median to severe pain were predictors of PONV.5-HT3 receptor antagonists prophylaxis or TIVA will decrease the incidence of PONV. Key words: Postoperative nausea and vomiting; Risk factors; Neurosurgical procedures; Anesthesia recovery period
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