Analysis of Risk Factors for Nonoperative Vertebral Refracture after Vertebroplasty for Single-Segment Vertebral Fracture

Abstract

Objective: To analysis the risk factors of nonsurgical vertebral refracture by making retrospectively study about patients with osteoporotic vertebral compression fractures (OVCF) had accepted vertebroplasty.Methods: From June 2016 to December 2017, there were 161 cases of OVCF patients were treated with single-segment vertebroplasty in our department, and follow-up data including age, gender, bone density, bone cement volume, bone cement puncture route, bone cement leakage and vertebral refracture were collected.T-test and chi-square test were used to analyze the possible risk factors for postoperative vertebral refracture.Results: Among 161 patients treated with vertebroplasty, 19 of them had refracture. Among the refracture group, including 2 males and 17 females,bone density (-3.49 + 0.20) in the refracture group, and bone density (-2.95 + 0.57) in the nonrefracture group.The difference was statistically significant (t=-4.162,P<0.001).Eight patients in the refracture group had cement intervertebral leakage, 11 patients in the nonre-fracture group had cement intervertebral leakage,24 patients in the nonre-fracture group had cement intervertebral leakage, and 138 patients in the nonre-fracture group had cement intervertebral leakage. The difference was statistically significant (chi-square = 6.928,P= 0.008).However, there was no statistically significant difference in age, gender, bone cement content, fracture history, surgical method, surgical site, puncture route and other factors.Conclusions: Decreased bone density and intervertebral leakage of bone cement may be risk factors for postoperative nonoperative vertebral refracture. Therefore, reasonable anti-osteoporosis treatment should be adhered to, and intervertebral leakage of bone cement should be minimized, to reduce the occurrence of postoperative refracture.