Abstract
Objective: To analysis the risk factors of nonsurgical vertebral refracture by making retrospectively study about patients with osteoporotic vertebral compression fractures (OVCF) had accepted vertebroplasty.Methods: From June 2016 to December 2017, there were 161 cases of OVCF patients were treated with single-segment vertebroplasty in our department, and follow-up data including age, gender, bone density, bone cement volume, bone cement puncture route, bone cement leakage and vertebral refracture were collected.T-test and chi-square test were used to analyze the possible risk factors for postoperative vertebral refracture.Results: Among 161 patients treated with vertebroplasty, 19 of them had refracture. Among the refracture group, including 2 males and 17 females,bone density (-3.49 + 0.20) in the refracture group, and bone density (-2.95 + 0.57) in the nonrefracture group.The difference was statistically significant (t=-4.162,P<0.001).Eight patients in the refracture group had cement intervertebral leakage, 11 patients in the nonre-fracture group had cement intervertebral leakage,24 patients in the nonre-fracture group had cement intervertebral leakage, and 138 patients in the nonre-fracture group had cement intervertebral leakage. The difference was statistically significant (chi-square = 6.928,P= 0.008).However, there was no statistically significant difference in age, gender, bone cement content, fracture history, surgical method, surgical site, puncture route and other factors.Conclusions: Decreased bone density and intervertebral leakage of bone cement may be risk factors for postoperative nonoperative vertebral refracture. Therefore, reasonable anti-osteoporosis treatment should be adhered to, and intervertebral leakage of bone cement should be minimized, to reduce the occurrence of postoperative refracture.
Highlights
At present, there are more and more patients with senile osteoporosis in China, and there are more and more patients with osteoporotic vertebral compression fractures (OVCF)
Single factor analysis of postoperative fractures in patients Univariate analysis showed that bone mineral density (BMD) and cement leakage were risk factors for refracture after PKP
Some studies have found that cement intervertebral space leakage is an important influencing factor for new vertebral fractures [2,3], which is consistent with the conclusions drawn by this study
Summary
There are more and more patients with senile osteoporosis in China, and there are more and more patients with OVCF. Vertebroplasty is the most commonly used surgical procedure for the treatment of OVCF, that has been widely used,because it has many advantages such as small trauma, rapid pain relief, quick recovery and so on[1]. The cause of refracture is not completely clear yet. This article will analyzes the patients who underwent vertebroplasty and discuss the possible risk factors for refracture
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