Abstract
BackgroundTo study the bacteriological characteristics, risk factors, and treatment of multi-drug resistance (MDR) organisms in patients with diabetic foot infection.MethodsPatients with diabetic foot ulcer admitted to hospital from June 2018 to December 2019 (n = 180) were selected as clinical subjects. Demographic information, routine blood test, wound culture and sensitivity were collected. Risk factors of MDR bacteria were analyzed.ResultsAmong 180 patients with diabetic foot ulcer, 146 were positive in bacterial culture, with 84 positive in MDR bacteria. A total of 182 strains were isolated, with 104 strains being multi-drug resistant. Body mass index, glycosylated hemoglobin, fasting blood glucose, triglyceride, course of ulcer, size of ulcer, peripheral neuropathy, peripheral vascular disease, osteomyelitis, peripheral blood leukocyte count, percentage of neutrophils, and previous use of antibiotics were the related factors of infection of MDR bacteria in diabetic foot ulcer patients (P < 0.05). The leukocyte count and neutrophil ratio of MDR-bacilli were lower than those of non MDR-bacilli (P < 0.05).ConclusionThe risk of MDR bacteria in diabetic foot infection is high. It is necessary to evaluate the risk of multidrug-resistant bacteria by characterizing the course of disease, metabolic control, local ulcer and other aspects in order to formulate an effective treatment plan. The decrease of leukocyte count and neutrophil ratio may be related to damage of the host immune response.
Highlights
To study the bacteriological characteristics, risk factors, and treatment of multi-drug resistance (MDR) organisms in patients with diabetic foot infection
The aim of this study is to analyze the bacteriological characteristics of diabetic foot ulcers, drug resistance of isolates, and to reveal the potential risk factors for multi-drug resistant bacteria
Bacteriological condition of diabetic foot ulcer infection A total of 180 patients with diabetic foot ulcers were included in this study, 146 (81.11%) were positive for wound culture, of which 62 (42.47%) had antibiotic-sensitive organisms and 84 (57.53%) had multidrug-resistant organisms
Summary
To study the bacteriological characteristics, risk factors, and treatment of multi-drug resistance (MDR) organisms in patients with diabetic foot infection. Diabetic patients often have a high prevalence of diabetic foot infection (DFI) due to associated neuropathy, peripheral vascular disease, immune abnormalities, etc. Some studies have shown that about 15% of diabetic patients can develop foot ulcers during their lifetime [1]. The aim of this study is to analyze the bacteriological characteristics of diabetic foot ulcers, drug resistance of isolates, and to reveal the potential risk factors for multi-drug resistant bacteria. This allows for more effective assessment and treatment plans for patients with MDR diabetic foot infections
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