Analysis of risk factors for initial poor graft function after liver transplantation

Abstract

Objective To analyze the risk factors for initial poor graft function (IPGF) after liver transplantation (LT). Methods Thirty-two cases who underwent liver transplantation from April to November in 2004 were selected randomly. The group of IPGF was confirmed if ALT and/or AST was above 1 500 U/L while non-IPGF below 1 500 IU/L within 3 days after LT. The recipient associated factors included age, MELD score, the donor associated factors included age, cold preservation time, score of liver biopsy at the end of cold ischemia and 4 h after portal vein perfusion, the score of biopsy about IRI, and the operation associated factors included operative time and RWIT. Results All recipients were followed up after LT. There were 10 cases in IPGF group and 22 cases in non-IPGF group. RWIT was (55.00±12.91) rain in IPGF group and (41.55±8.55) rain in non- IPGF group respectively (P 0.05). By score of Po and IRI, the rate of IPGF was higher in severe injury group than in mild and moderate group (P<0.05). Conclusion By binary logistic regression, RWIT and IRI were the risk factors for 1PGF. Key words: Liver transplantation; Hepatic insufficiency; Biopsy; Prognosis