Abstract
Objectives:To determine the clinical characteristics and risk factors of Deep Venous Thrombosis (DVT) in patients with gynecological malignant tumor, facilitating gynecologists better prevent the fatal complication.Methods:The patients with gynecological malignant tumor treated in department of gynecology of our hospital between May 2013 and May 2018 were reviewed retrospectively. The clinical data of patients including gender, age, tumor staging, adenocarcinoma, surgery, operation time, hypertension, hyperlipemia, diabetes, coronary heart disease, radiotherapy, chemotherapy, hospital stay, and postoperative rehabilitation exercise were collected to analyze the clinical characteristics of patients and determine the risk factors of DVT.Results:In the current study, 67 patients were included in DVT group, and 554 patients were included in Non-DVT group. There were significant differences in age, hypertension, hyperlipemia, operation time, adenocarcinoma, tumor staging, radiotherapy and postoperative rehabilitation exercises between DVT and non-DVT groups (p<0.05). However, there was no significant differences in gender, coronary heart disease, diabetes, surgical treatment and hospital stay (p>0.05). In multivariate analysis, the factors including age, hypertension, adenocarcinoma, radiotherapy, and hyperlipemia were independent risk factors, while rehabilitation exercise was protective factor for DVT.Conclusion:In cases of gynecological malignant tumor, DVT screening should be given due importance, especially for those patients with old age, hypertension, hyperlipemia, adenocarcinoma, or history of radiotherapy. Rehabilitation exercise should be encouraged in these patients.
Highlights
Gynecological cancer is the leading cause of cancer-related death in women,[1] and deep vein thrombosis (DVT) is one of the most common complications in patients with gynecological cancer
The clinical data of patients including gender, age, tumor staging, adenocarcinoma, surgery, operation time, hypertension, hyperlipemia, diabetes, coronary heart disease, radiotherapy, chemotherapy, hospital stay, and postoperative rehabilitation exercises were collected to analyze the clinical characteristics of patients and determine the risk factors of DVT
Hypertension was defined as blood pressure above 140/90 mmHg9, and hyperlipemia was defined as an elevated total cholesterol level above 6.22 mmol/L, or triaglyceride level above 2.26 mmol/L, or low-density lipoprotein level above 4.14 mmol/L10, and other disease such as diabetes and coronary heart disease were diagnosed according to corresponding criteria.[11,12]
Summary
Gynecological cancer is the leading cause of cancer-related death in women,[1] and deep vein thrombosis (DVT) is one of the most common complications in patients with gynecological cancer. In a study of 87 patients with ovarian cancer, Kawaguchi reported the incidence of DVT was 16.1%.2. Some patients with DVT may develop into pulmonary embolism (PE), which leads to a high mortality rate.[3] Gynecological malignant tumor usually needs surgical treatment, Pak J Med Sci January - February 2019 Vol 35 No 1 www.pjms.org.pk 195 which may aggravate the occurrence of DVT. Geerts reported the risk of DVT after gynecologic surgery was high up to 17-40%.4. The fatal complication is given due importance in gynecological department.[5] Geerts reported the risk of DVT after gynecologic surgery was high up to 17-40%.4 Subsequently, the fatal complication is given due importance in gynecological department.[5]
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