Analysis of risk factors for blood vessel invasion in stage I non-small cell lung cancer

Abstract

Objective To analyze the risk factors of blood vessel invasion in stage Ⅰ non-small cell lung cancer (NSCLC). Methods A retrospective analysis of 166 patients with stage Ⅰ NSCLC who underwent surgical resection and pathological diagnosis from January 2016 to March 2018 in China-Japan Friendship Hospital was conducted. The presence of blood vessel invasion in tumor tissue was detected by immunohistochemistry. Clinicopathological factors which may affect blood vessel invasion were evaluated by univariate analysis and multiple logistic regression analysis. For statistically significant factors revealed by multivariate analysis, the diagnostic efficiency and best cut-off point were calculated by the receiver operating characteristic curve. Results The univariate analysis identified that the smoking history (P = 0.020), maximum standardized uptake value (SUVmax) (P = 0.001), tumor diameter (P = 0.001), TNM stage (P = 0.002), and lymphatic invasion (P = 0.023) were factors affecting blood vessel invasion status. Multivariate analysis showed that SUVmax was an independent risk factor for blood vessel invasion (OR = 1.097, 95% CI 1.014-1.187, P = 0.021). The preoperative SUVmax of primary tumor was a predictor for blood vessel invasion with the highest diagnostic accuracy at a cut-off value of 4.85, the sensitivity and specificity were 66.0% and 71.7%, respectively. Conclusion The SUVmax is an independent predictor for blood vessel invasion in stage Ⅰ NSCLC, and the risk of blood vessel invasion rises with the increase of SUVmax. Key words: Carcinoma, non-small-cell lung; Neoplasm invasiveness; Blood vessel invasion; Risk factors