Abstract
PurposeTo analyze the retinal and choroidal thickness in the macular area in patients with Parkinson's disease (PD) using swept‐source optical coherence tomography (SS‐OCT) as a marker for neurodegenerative injury.Methods108 eyes of patients with PD and 90 eyes of healthy controls were included. All subjects underwent ophthalmologic evaluation including retinal and choroidal assessment using SS‐OCT Triton (Topcon), 3DH Wide protocol. Macular ETDRS data were analyzed, including retinal and choroidal thickness evaluation.ResultsPatients with PD revealed significant thinning compared to healthy controls concerning the outer nasal region of macular thickness (276.70 ± 17.64 μm in patients vs. 282.44 ± 9.64 μm in controls; p = 0.043). Regarding choroidal thickness, patients with PD revealed significant thickening compared to healthy controls in the inner nasal region (250.78 ± 99.50 μm in patients vs. 205.28 ± 81.62 μm in controls; p = 0.014), outer nasal region (207.11 ± 97.78 μm vs. 163.39 ± 70.02 μm; p = 0.011), inner inferior region (252.25 ± 96.54 μm vs. 213.65 ± 80.31 μm; p = 0.032) and outer inferior region (233.00 ± 89.10 μm vs. 200.15 ± 75.19 μm; p = 0.049).ConclusionsPD patients present reduced retinal thickness and increased choroidal thickness in the macular area compared to healthy subjects detectable with new SS‐OCT technology.
Published Version
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