Abstract
慢性乙型肝炎患者在抗病毒治疗过程中可出现持续低病毒载量血症的现象，但原因未明，耐药变异可能是其原因之一。共纳入15例有完整的随访资料，血清和肝组织样本（0周和104周）的患者，均使用替比夫定作为初始抗病毒治疗方案，根据病毒学应答继续单独使用替比夫定或加用阿德福韦酯。使用Sanger测序和Illumina二代测序检测核苷类似物相关耐药变异，结果提示8例持续低，病毒载量血症者均未发现核苷酸类似物相关耐药变异的存在。.
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Schedule a callMore From: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
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