Abstract
Background and aimThe Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between RAMP3 gene variants, body composition and bone phenotypes in two population-based cohorts of Swedish women.MethodsFive single nucleotide polymorphisms (SNP) in the vicinity of the RAMP3 gene were genotyped in the PEAK-25 cohort (n = 1061; 25 years) and OPRA (n = 1044; 75 years). Bone mineral density (BMD), fat mass and lean mass (total body; regional) were measured by DXA at baseline, 5 and 10 year follow-up.ResultsBMD did not differ with RAMP3 genotype in either cohort, although fracture risk was increased in the elderly women (OR 2.695 [95% CI 1.514–4.801]). Fat mass tended to be higher with RAMP3 SNPs; although only in elderly women. In the young women, changes in BMI and fat mass between ages 25–35 differed by genotype (p = 0.001; p < 0.001).ConclusionVariation in RAMP3 may contribute to age-related changes in body composition and risk of fracture.
Highlights
Osteoporosis is a common disease in our aging society, affecting one in three women during the course of their lifetime (Melton 3rd et al, 1992)
In Osteoporosis Prospective Risk Assessment (OPRA), carriers of single nucleotide polymorphisms (SNP) rs2074654 minor ‘C' allele tended towards slightly higher values of both fat (TB-Fat Mass (FM) 2.21% difference), and lean mass (TB-Lean Mass (LM) 1.34%), after adjustment for body size, p-values increased at some sites (Table 4)
The objective of the present study was to determine the association between receptor activity modifying protein 3 (RAMP3) variants with body composition, bone density and fracture
Summary
Osteoporosis is a common disease in our aging society, affecting one in three women during the course of their lifetime (Melton 3rd et al, 1992) It is characterized by reduced bone mineral density (BMD), and quantitative and qualitative changes to bone tissue, the clinical result of which is an increased risk of fractures (Anonymous, 1993). Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between RAMP3 gene variants, body composition and bone phenotypes in two population-based cohorts of Swedish women. Conclusion: Variation in RAMP3 may contribute to age-related changes in body composition and risk of fracture
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
