Analysis of radiotherapy strategy for 110 breast cancer patients after R0 resection of local recurrence after radical mastectomy

Abstract

Objective To explore the effect of prognosis of consolidation radiotherapy for patients after R0 resection of local recurrence after radical mastectomy. Methods Totally 110 breast cancer patients with local recurrence receiving R0 resection were admitted and treated in our hospital from January 1st, 2003 to November 30th, 2015 were retrospectively analyzed. Results The median local progression time of 74 patients receiving consolidation radiotherapy(67.3%)was remarkably better than that of those without radiotherapy(36 patients, 32.7%), and the difference was statistically significant (χ2=8.526, P 0.05) of distance disease-free survival and overall survival between the radiotherapy group and the non-radiotherapy group. Multifactor analysis indicated that pseudo-adjuvant endocrine therapy(χ2=7.541, 95%CI: 27.1%-80.4%, P<0.05), DDFS(≥2 years vs.<2 years, χ2=4.068, 95%CI: 101.4%-267%, P<0.05) and pseudo-adjuvant radiotherapy(χ2=14.126, 95%CI: 21.7%-80.4%, P<0.05) were the independent risk factors affecting the OS of patients with local recurrence after R0 resection. Conclusions For the patients with local recurrence after R0 resection of local recurrence, it is recommended that consolidation radiotherapy should be done and the radiation field should include the same side of the chest wall and clavicle area lymphatic drainage area. Key words: Breast cancer; Local regional recurrence; Radiotherapy