Abstract
Background: Prostate cancer is the most common cancer in men. Prostate specifi c antigen is a key tumor marker to screen for prostate cancer. However, controversy exits regarding the impact of prostate cancer screening. Materials and Methods: This was a retrospective study carried out in the Department of Histopathology of B and B Hospital during a period of 2 years from 01-05-2064 to 01-05-2066. The study included 26 cases of prostate needle biopsy specimens. Results: The more common age group (43.9%) was 70-79 years followed by the age group above 80 years old (7.5%). The most common benign lesion observed was benign prostatic hyperplasia (5 out of 11, 45.45%), followed by benign prostatic hyperplasia with chronic prostatitis (3 out of 11, 27.27%). The most common malignant types of lesion encountered was prostatic adenocarcinoma with an incidence of 84.62% (11 out of 13 cases), following nodular hyperplasia of prostate with low grade prostatic intraepithelial neoplasm 15.38% (2 out of 13 cases). Among the benign and the malignant cases serum PSA ranged from 0 - ?10.1 ng/ml. Conclusion: Serum PSA value has signifi cant role in the diagnosis of malignant prostatic lesions. However, Histological diagnosis still remains the gold standard for the diagnosis of prostatic cancer. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 394-396 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7865
Highlights
Prostate is a glandular organ in males, enveloped by a fibromuscular layer
Light microscopic study was done to look for features of benign prostatic hyperplasia (BPH), chronic prostatitis, prostatic intraepithelial neoplasm (PIN), prostatic adenocarcinoma and other changes
The age range was 30-94 years with mean age of 62 years 46.15% of malignant lesions were seen in the age group between 70-79 years and 36.37% of benign lesions were seen with the same age group
Summary
Prostate is a glandular organ in males, enveloped by a fibromuscular layer. A conglomerate of lesions affects this organ, among which benign prostatic hyperplasia (BPH), chronic prostatitis, prostatic intraepithelial neoplasm (PIN) and prostate cancer are the leading cause of morbidity in the middle aged and elderly males.[1]Correspondence: Chronic prostatitis is more common than acute prostatitis and is the “black sheep” of the prostate family of disease, because of the difficulty to completely treat such a disease.[2]Prostatic Intraepithelial Neoplasia is characterized by cellular proliferations within pre-existing ducts and glands with cytologic changes mimicking adenocarcinoma but lacking stromal invasion.Prostate Cancer is the most common urological malignancy and is second only to lung cancer as a leading cause of cancer related deaths in men. Prostate is a glandular organ in males, enveloped by a fibromuscular layer. A conglomerate of lesions affects this organ, among which benign prostatic hyperplasia (BPH), chronic prostatitis, prostatic intraepithelial neoplasm (PIN) and prostate cancer are the leading cause of morbidity in the middle aged and elderly males.[1]. Prostatic Intraepithelial Neoplasia is characterized by cellular proliferations within pre-existing ducts and glands with cytologic changes mimicking adenocarcinoma but lacking stromal invasion. Prostate Cancer is the most common urological malignancy and is second only to lung cancer as a leading cause of cancer related deaths in men. Prostate cancer is the most common cancer in men. Prostate specific antigen is a key tumor marker to screen for prostate cancer. Controversy exits regarding the impact of prostate cancer screening
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