Abstract
Objective To investigate the risk factors of clinical prognosis of mass-forming intrahepatic cholangiocarcinoma (ICC) patients after surgical resection. Methods Clinical data of 48 patients with mass-forming ICC who underwent surgical resection in PLA General Hospital from January 2010 to October 2016 were retrospectively analyzed. The informed consents of all patients were obtained and the local ethical committee approval was received. Among them, 33 patients were male and 15 were female, aged from 29 to 73 years with a median age of 53 years. Tumors were located in the right lobe of the liver in 37 cases and left lobe in 11 cases. The mean tumor diameter was (6.8±2.6) cm. All patients underwent R0 resection. The clinicopathological parameters were included in the analysis of prognostic factors. Kaplan-Meier survival curve and Log-rank test were conducted for univariate analysis. Cox's proportional hazard model was conducted for multivariate analysis. Results During the postoperative follow-up, 28 cases died and 20 cases survived. The survival time was 3-82 months with a median survival time of 20 months. The 1-, 3- and 5-year survival rate was 95.7%, 50.9% and 14.8%, respectively. Univariate analysis indicated that HBsAg, degree of tumor differentiation, lymph node metastasis and vascular invasion were the impact factors for the survival prognosis (χ2=4.097, 6.415, 11.069, 9.117; P<0.05). Multivariate analysis revealed that lymph node metastasis was an independent risk factor for the prognosis of patients undergoing surgical resection (HR=3.306, 95%CI: 1.184-9.233; P<0.05). Conclusion Lymph node metastasis is an independent risk factor for the clinical prognosis of mass-forming ICC patients after surgical resection. Key words: Intrahepatic cholangiocarcinoma; Hepatectomy; Prognosis; Risk factors
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