Abstract
BackgroundSoft tissue sarcoma is one cause of mortality in adult malignancies. This tumor is rare, persistent, and highly-recurrent. Many patients are came in late stage. It is important to identify a prognostic tool that is reliable, easily obtainable, and widely applicable. The aim of this study is to investigate and analyze the prognostic value of clinicopathological and biomarker factors in patients with soft tissue sarcoma. MethodsThis retrospective study extracts data from the musculoskeletal tumor registry from January 2012 to December 2018 in a single tertiary hospital. Eighty patients with diagnosis of soft tissue sarcoma were included. Preoperative modified Glasgow Prognostic Score, Neutrophils/Lymphocytes Ratio, Hemoglobin, serum lactate dehydrogenase data were analyzed along with demographic, clinical, radiological and histopathological data. The relationship between variables on overall survival, distant metastasis, and local recurrence were evaluated using univariate and multivariate Cox regression. ResultsOn univariate analysis, there was significant relationship between hemoglobin, Neutrophils/Lymphocytes Ratio and modified Glasgow Prognostic Score with overall survival (p = 0.031, HR = 1.99; p = 0.04, HR = 1.129; and p = 0.044, HR = 3.89). A significant relationship was found between age and soft tissue sarcoma stage with distant metastasis (p = 0.046, HR = 1.95; and p = 0.00, HR = 3.22). In addition, we also found significant relationship between surgical margin with local recurrence (p = 0.018, OR = 3.44). However, on multivariate analysis the independent prognostic factor for overall survival was only modified Glasgow Prognostic Score (HR = 2.138; p = 0.011). Stage IIIA (HR = 5.32; p = 0.005) and IIIB (HR = 13.48; p = 0.00) were independent prognostic for distant metastasis. Surgical margin was independently associated with local recurrence (HR = 14.84; p = 0.001). ConclusionModified Glasgow Prognostic Score can be used as prognostic tool of overall survival in soft tissue sarcoma patients. Moreover, stage of STS and surgical margin can be used as a prognostic factor for distant metastasis and local recurrence of soft tissue sarcoma respectively.
Highlights
Soft tissue sarcoma (STS) is a rare and persistent malignant tumor originating in mesenchymal tissue of any organs except bones and cartilage
Majority of the patients were in 40–60 years old (41.3%) followed with the age group of 20–40 years old (3.8%)
Multivariate analysis showed that modified Glasgow Prognostic Score (mGPS) was the only independent prognostic factor for overall survival (OS) in soft tissue sarcoma patients (HR = 2.138; CI = 1.187–3.851)
Summary
Soft tissue sarcoma (STS) is a rare and persistent malignant tumor originating in mesenchymal tissue of any organs except bones and cartilage. It constitutes only 1–2% of malignancies in adults. It is important to identify a prognostic tool that is reliable, obtainable, and widely applicable to improve the ability of risk stratification and to help with treatment.
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