Analysis of prognosis-related factors for pancreatic neuroendocrine tumors

Abstract

Objective To analyze retrospectively the clinicopathological characteristics of pancreatic neuroendocrine tumors(PNETs) and investigate the prognosis-related factors associated with tumor recurrence and survival. Methods Data of 96 patients with PNETs were analyzed retrospectively. Results A total 76 patients was included in this study, 65 patients in surgery group, and 11 in non-surgery group. The mean overall survival in surgery group was (36.6±30.4)months. The 1-, 3-, and 5-year overall survival rates were 95.4%, 84.6%, and 84.6%, respectively. Multivariate analysis showed that lymph node metastasis, G3 histological grade, and major vascular invasion were significantly associated with survival of PNETs (P<0.05). The mean disease-free survival was (31.5±29.1)months. The 1-, 3-, and 5-year disease-free Survival rates were 12.3%, 24.6%, and 29.2%, respectively. Multivariate analysis showed that lymph node metastasis and pancreatic neuroendocrine carcinoma were significantly associated with recurrence of PNETs (P<0.05). The mean overall survival in non-surgery group was (15.0±10.3) months. The 1-, and 3-year overall survival rates were 63.6% and 36.4%, respectively. Compared to 6 patients presented distant metastasis in surgery group, the non-surgery group is associated with a shorter mean overall survival(OS)[(15.0±10.3)months vs (39.3±42.1)months], and lower 1-, and 3-year overall survival rate. Conclusions Lymph node metastasis, G3 histologcial grade, and major vascular invasion were independent predictive factors of worse overall survival in patients with PNETs. Lymph node metastasis and pancreatic peuroendocrine carcinoma were found to be independent risk factors influencing recurrence. In series of patients of PNETs with advance stage, surgery seemed to improve survival, but further study is needed. Key words: Pancreatic neoplasms; Neuroendocrine tumors; Prognosis; Risk factors