Analysis of prognosis and recurrent factors of primary retroperitoneal liposarcoma

Abstract

Objective To investigate the prognosis and recurrent factors of primary retroperitoneal liposarcoma (PRPLS). Methods The retrospective case-control study was conducted. The clinicopathological data of 51 patients with PRPLS who were admitted to the Southwest Hospital of the Third Military Medical University from January 2005 and March 2015 were collected. Observation indicators: (1) follow-up institution. (2) Analysis of prognostic factors: gender, age, tumor diameter, combined organs resection, pathological type, cancer risk and local recurrence. (3) Analysis of recurrent risk factors: gender, age, tumor diameter, combined organs resection, pathological type and cancer risk. (4) Stratified analysis: the independent risk factors of recurrence were done by the stratified analysis. (5) Correlation between cancer risk and tumor diameter or number of organs invaded. (6) Correlation between adjacent organ invasion and tumor diameter. Follow-up using outpatient examination and telephone interview was performed to detect the survival of patients and tumor recurrence up to October 2015. The survival rate and curve were respectively calculated and drawn by Kaplan-Meier method. The univariate analysis and survival analysis were done using the Log-rank test. The multivariate analysis was done by the COX regression model. The correlation analysis was done using the Pearson test. Results (1) Follow-up institution: 51 patients were followed up for 3-114 months, with a median time of 43 months. The 3-year survival rate of 51 patients was 70.6%. Twenty-two patients had the first local recurrence, with a recurrent time of 3-60 months and a median time of 29 months. (2)Analysis of prognostic factors: the results of univariate analysis showed that tumor diameter, combined organs resection, pathological type, cancer risk and local recurrence were the related factors affecting prognosis of patients with PRPLS (χ2=5.926, 4.936, 17.856, 17.279, 14.568, P 0.05) and with a statistically significant difference in number of organs invaded (r=0.666, P 0.05). Conclusions The combined organs resection, pathological type and cancer risk are independent factors affecting prognosis of patients with PRPLS, and cancer risk is an independent factor affecting recurrence of patients with PRPLS. The prognosis of patients with low risk of PRPLS is better than that with high risk of PRPLS. The organ invaded is much likely to occur in patients with high risk of PRPLS. Key words: Primary retroperitoneal liposarcoma; Prognosis; Recurrence