Analysis of prognoseic factor on intermittent hormonal therapy for patients with prostate cancer

Abstract

Objectives To investigate the efficacy of the intermittent hormonal therapy (IHT) in the treatment of prostate cancer.Methods The IHT materials 130 cases of patients with prostate cancer were analyzed retrospectively,the cases must be satisfying the condition that has been settled.Maximal androgen blockade (MAB) therapies were used for several months,and then stopped until the serum prostate specific antigen (PSA) was decreased below 0.2ng/mL,which lasted for three months to six months.It was decided whether MAB went on according to if the level I of PSA is higher than 10ng/mL.Analyze the information of intermittent hormonal therapy and the time arriving CRPC to find the Predicative factors that related to the effect of the intermittent hormonal therapy.Results The average follow up time was 1063 ± 682 days.Ninety five patients started the second cycle of treatment,thirty nine patients started the third cycle and thirteen entered the fourth.The patients with nPSA below 0.1 ng/mL or PSAV below-15ng/mL/year experienced longer time to change to CRPC.PSAV and nPSA are the independent risk factors for the time cost for turning to CRPC.Conclusions The analysis of the Prediction of intermittent hormonal therapy efficacy indicates that nPSA and PSAV are the independent factors that predicate the efficacy of intermittent hormonal therapy.Intermittent hormonal therapy is more effective and proper for the patient with nPSA ＜0.1 ng/mL or PSAV ＜-15ng/mL/year. Key words: Prostatic Neoplasms ; Prognosis