Abstract
Objective: to study the probable laboratory predictors of aggressive multiple sclerosis.Materials and methods. Antibodies to myelin oligodendrocyte glycoprotein (MOG), antibodies to thyroperoxidase and markers of endothelial dysfunction in blood serum were determined in patients with multiple sclerosis (MS). These indicators were analyzed for different courses of the demyelinating process, for different severity of neurological disorders, and for various sizes of focal lesions on magnetic resonance images.Results. In patients with aggressive multiple sclerosis, higher titers of antibodies to both myelin oligodendrocyte glycoprotein and thyroperoxidase were detected. A relationship between von Willebrand factor (vWf) and matrix metalloproteinase-9 (MMP-9) and the stage of multiple sclerosis was identified. A higher level of matrix metalloproteinase-9 was detected in MS patients with active foci of the disease on magnetic resonance images.Conclusion. Thus, antibodies to myelin oligodendrocyte glycoprotein, antibodies to thyroperoxidase, the levels of von Willebrand factor, matrix metalloproteinase-9 and adhesion molecule sPECAM-1 can be used as laboratory predictors of the malignant course of multiple sclerosis.
Highlights
In patients with aggressive multiple sclerosis, higher titers of antibodies to both myelin oligodendrocyte glycoprotein and thyroperoxidase were detected
A higher level of matrix metalloproteinase-9 was detected in multiple sclerosis (MS) patients with active foci of the disease on magnetic resonance images
Antibodies to myelin oligodendrocyte glycoprotein, antibodies to thyroperoxidase, the levels of von Willebrand factor, matrix metalloproteinase-9 and adhesion molecule sPECAM-1 can be used as laboratory predictors of the malignant course of multiple sclerosis
Summary
Анализ возможных предикторов злокачественного течения рассеянного склероза Спирин Н.Н., Киселева Е.В., Спирина Н.Н. Ó ïàöèåíòîâ, èìåþùèõ ïðèçíàêè çëîêà÷åñòâåííîãî òå÷åíèÿ ðàññåÿííîãî ñêëåðîçà, íàáëþäàëèñü áîëåå âûñîêèå òèòðû àíòèòåë ê ìèåëèí-îëèãîäåíäðîöèòàðíîìó ãëèêîïðîòåèíó è àíòèòåë ê òèðåîïåðîêñèäàçå. Áûëà âûÿâëåíà ñâÿçü ôàêòîðà ôîí Âèëëåáðàíäà è ìàòðèêñíîé ìåòàëëîïðîòåèíàçû-9 ñî ñòàäèåé ðàññåÿííîãî ñêëåðîçà. Íà îñíîâàíèè ïðåäñòàâëåííûõ ðåçóëüòàòîâ â êà÷åñòâå ëàáîðàòîðíûõ ïðåäèêòîðîâ çëîêà÷åñòâåííîãî òå÷åíèÿ ðàññåÿííîãî ñêëåðîçà ìîæíî ðàññìàòðèâàòü óðîâåíü àíòèòåë ê ìèåëèí-îëèãîäåíäðîöèòàðíîìó ãëèêîïðîòåèíó, àíòèòåë ê òèðåîïåðîêñèäàçå, óðîâåíü àíòèãåíà ôàêòîðà ôîí Âèëëåáðàíäà, ìàòðèêñíîé ìåòàëëîïðîòåèíàçû-9, ìîëåêóëû àäãåçèè sPECAM-1, íî òðåáóåòñÿ àíàëèç äàííûõ ïîêàçàòåëåé ó áîëüøåãî êîëè÷åñòâà ïàöèåíòîâ. Êëþ÷åâûå ñëîâà: ðàññåÿííûé ñêëåðîç, çëîêà÷åñòâåííîå òå÷åíèå ðàññåÿííîãî ñêëåðîçà, àíòèòåëà ê ìèåëèí-îëèãîäåíäðîöèòàðíîìó ãëèêîïðîòåèíó, àíòèòåëà ê òèðåîïåðîêñèäàçå, ôàêòîð ôîí Âèëëåáðàíäà. Àâòîðû äåêëàðèðóþò îòñóòñòâèå ÿâíûõ è ïîòåíöèàëüíûõ êîíôëèêòîâ èíòåðåñîâ, ñâÿçàííûõ ñ ïóáëèêàöèåé íàñòîÿùåé ñòàòüè. Àâòîðû çàÿâëÿþò îá îòñóòñòâèè ôèíàíñèðîâàíèÿ ïðè ïðîâåäåíèè èññëåäîâàíèÿ. Анализ возможных предикторов злокачественного течения рассеянного склероза
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