Analysis of Predictive Model of Coronary Vulnerable Plaque under Hemodynamic Numerical Simulation.

Qiang Song,Mingwei Chen,Zhi Hu,Hui Cai,Jin Shang,Osamah Ibrahim Khalaf

doi:10.1155/2022/3434910

Abstract

Objective Vulnerable plaque is considered to be the cause of most clinical coronary arteries, and linear cytokines are an important factor causing plaque instability. Early prediction of vulnerable plaque is of great significance in the treatment of cardiovascular diseases. Methods Computational fluid dynamics (CFD) was used to simulate the hemodynamics around plaques, and the serum biochemical markers in 224 patients with low-risk acute coronary syndrome (ACS) were analyzed. Vulnerable plaques were predicted according to the distribution of biochemical markers in serum. Results CFD can accurately capture the hemodynamic characteristics around the plaque. The patient's age, history of hyperlipidemia, apolipoprotein B (apoB), adiponectin (ADP), and sE-Selection were risk factors for vulnerable plaque. Area under curve (AUC) values corresponding to the five biochemical markers were 0.601, 0.523, 0.562, 0.519, 0.539, and the AUC value after the combination of the five indicators was 0.826. Conclusion The combination of multiple biochemical markers to predict vulnerable plaque was of high diagnostic value, and this method was convenient and noninvasive, which was worthy of clinical promotion.

Highlights

IntroductionIn China, cardiovascular diseases account for about half of the deaths caused by diseases and have become the number one cause of death in China
Cardiovascular disease has become the leading cause of death worldwide
E outer membrane is composed of loose connective tissue rich in elastic fibers and collagen fibers, which is responsible for supporting the vascular wall of the body [4]. e media is located between the intima and the outer membrane, and its composition and thickness vary with different blood vessel types in the human body [5]

Summary

Introduction

In China, cardiovascular diseases account for about half of the deaths caused by diseases and have become the number one cause of death in China. In terms of anatomical structure, arterial vessels are divided into the intima, media, and outer membrane from inside to outside. E intima, as the innermost layer of vascular wall, is the thinnest in structure and mainly composed of the endothelium and subendothelial layer [3]. E outer membrane is composed of loose connective tissue rich in elastic fibers and collagen fibers, which is responsible for supporting the vascular wall of the body [4]. E media is located between the intima and the outer membrane, and its composition and thickness vary with different blood vessel types in the human body [5]. The endothelial cells of the blood vessels in the intima are usually seen in direct contact with the blood. erefore, it is mainly affected by the combined effect of the wall shear stress (WSS) of blood on the vascular wall and the peripheral circumferential stress (CS) of the solid [6, 7]

Methods

Results

Conclusion