Abstract
The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV is currently limited. Therefore, it is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV. This data is relevant in the design and development of vaccine and other therapeutic candidates for further consideration.
Highlights
Japanese Encephalitis (JEV) is an infection, which belongs to the family of Flaviviridae
We report a preliminary analysis of predicted proteasomal cleavage data in the methyltransferase domain from Japanese Encephalitis Virus (JEV)
It is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV
Summary
Japanese Encephalitis (JEV) is an infection, which belongs to the family of Flaviviridae. It is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV towards the development of suitable therapeutics against the virus. Figures 2: The protein sequence of the MTase domain from JEV is shown with (A) secondary structures and (B) conserved domains. It consists of two domains (MTase and RdRP) as shown.
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