Analysis of pre- and post-donation haematological values in plateletpheresis donors

Abstract

Abstract The post-procedure haematological values of donor in plateletpheresis have received relatively little attention. The present study is aimed to study reductions in haematological values after plateletpheresis. The total 100 successful plateletpheresis procedures were performed with Haemonetics ® MCS ® LN09000 – 220E/ED system at apheresis unit of tertiary care centre. To measure the pre- and post-donation haematological values, whole blood samples were collected in EDTA vials just before and within 30min after the procedure. Parameters, including Hb concentration, haematocrit, platelet and WBC counts, mean platelet volume (MPV), platelet distribution width (PDW), etc. were measured. The total mean reduction of 81.980×10 9 per litre in platelet count is noticed with mean pre-donation platelet count 312×10 9 per litre and mean post-donation platelet count 230×10 9 per litre. The total mean reduction of 0.85g/dL in total haemoglobin, decrease of 1.22% in HCT and reduction of 0.561 in ×10 9 per litre total WBC count are noticed. The total mean reduction of 0.2×10 12 per litre in total RBC count, decrease of 0.57pg in MCH, decrease of 0.82g/dL in MCHC is noticed. P -value is statistically significant and So it is recommended that apheresis donors with low normal pre-procedure platelet counts (150–200×10 9 per litre) and Hb concentration (12.5–13g/dL) should be examined for post-donation decrease in the platelet and other haematological parameters. Donors with significant decrements should be reviewed subsequently to exclude or, if necessary, treat thrombocytopenia and iatrogenic anaemia.