Analysis of postoperative life quality and influence factors of patients with hematopoietic stem cell transplantation

Abstract

Objective To investigate the life quality of postoperative patients with hematopoietic stem cell transplantation (HSCT) and analyze its influencing factors, thus putting forward suggestions for follow-up visits and intervention of postoperative patients with HSCT. Methods A total of 64 cases of postoperative patients with HSCT in Beijing University Shenzhen Hospital and 36 cases of postoperative patients with HSCT in Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University were chosen as research objects from October 2003 to October 2013. The General Information Questionnaire and the World Health Organization Quality of Life-Brief (WHOQOL-BREF) were adopted to investigate the patients' quality of life. The General Information Questionnaire included gender, age, marital status, education level, disease types, the severity of graft versus host disease (GVHD), the types of transplantation, transplantation time and so on. The WHOQOL-BREF included four dimensions: physiological, psychological, environmental and social relations dimension. It consisted of 26 items and each item was one to five scores, the full mark was 130 scores. The survey results about postoperative life quality of patients with HSCT were analyzed by univariate analysis and multivariate analysis. The study protocol was approved by the Ethical Reviews Board of Investigation in Human Being of Beijing University Shenzhen Hospital and Sun Yat-Sen Memorial Hospital. Informed consent was obtained from all participants. Results ①The life quality scores of 100 patients were from 61 to 124 scores and the average scores was (96.6±12.1) scores which was in the medium level. The score of economic status item was lowest, only 15% patients thought that their economic conditions could meet the needs of treatment cost. ②Univariate analysis results showed that the quality of life after transplantation was closely related to these influencing factors: the transplant type, severity of GVHD, time after transplantation, working conditions and financial situation (P<0.05). The multiple linear regression analysis results of the 4 dimensions in WHOQOL-BREF showed that the descending order of influencing degree on the patients' quality of life after HSCT was physiological field, psychological field, environmental field and social relations field. Physiological field dimension was the most relevant dimension with patients' quality of life among four dimensions (R2=0.815, P=0.000). Conclusions The life quality of HSCT postoperative survivors is not high which should be improved. It prompts medical workers to strengthen the follow-up visits and take some corresponding intervention measures to maximally reduce their body pain, meet their spiritual needs, in order to improve the life quality of patients after HSCT operation. Key words: Hematopoietic stem cell transplantation; Quality of life; Influential factor