Abstract
EMIT, normally used on urine or serum for the detection of drugs of abuse, has been utilized for the analysis of drugs in aqueous brain extracts. A modified Stas-Otto procedure performed on the brain tissue produced a liquid containing no interfering substances. The detection limits proved to be at least as sensitive as the chromatographic screening techniques normally applied to larger portions of the final aqueous filtrate. Out of 166 cases, 50 positive findings were determined. Two glutethimide cases gave positives for the barbiturate assay and a fatal overdose of amitriptyline appeared positive when tested with the benzodiazepine reagents. All other positive findings correlated well with the chromatographic findings.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.