Analysis of possible antidepressant effects of Cordia Myxa extract in male rats

Abstract

Depression is one of the most frequent psychiatric illnesses, and it is treated with a number of drugs that have serious side effects on human health and lead to a rise in suicide rates. Due to their safety, efficacy, and cost-effectiveness, herbal drugs have lately sparked a lot of interest in the treatment of depression. As a result, the goal of this study was to see how C.Myxa fruit extract affected a model of chronic unexpected stress (CUS). Six groups of sixty male rats were formed as a result. Group 1 (control) was not exposed to CUMS and did not receive any treatment, whereas group 2 was exposed to CUMS for 24 days and received normal saline treatment for 14 days, group 3 was exposed to CUMS for 24 days and received 10 mg/kg fluoxetine daily on day 10 for 14 days, and groups 4,5 and 6 were exposed to CUMS for 24 days and received C.Myxa extract (125, 250, and 500 mg/kg respectively) on day 10 for 14 days. Open field test groomings and line crossing frequency were used to assess the antidepressant impact of fluoxetine and C.Myxa extract.