Abstract
The application of renewable raw materials encourages research in the biopolymers area. The Poly(Lactic-co-Glycolic Acid)/Poly(Isoprene) (PLGA/IR) blend combines biocompatibility for application in the health field with excellent mechanical properties. The blend was obtained by solubilization of polymers in organic solvents. To investigate the polymer thermochemical properties, FTIR and DSC were applied. To investigate the composition's influence over polymer mechanical properties, tensile and hardness test were applied. To analyze the blends response in the cell environment, a stent was produced by injection molding process, and Cell Viability Test and Previous Implantability were used. The Infrared spectra show that chemical composition is related only with polymers proportion in the blend. The calorimetry shows a partial miscibility in the blend. The tensile test shows that adding Poly(Isoprene) to Poly(Lactic-co-Glycolic Acid) induced a relevant reduction in the Young modulus, tensile stress and tenacity of the material, which was altered from the fragile raw PLGA to a ductile material. The composition did not affect the blend hardness. The cell viability test shows that the blend has potential application as biomaterial, while the first results of implantability indicate that the polymeric stent kept its original position and caused low fibrosis.
Highlights
The use of biologically derived polymers of other polymers into the material[1]
The goal of this study was to investigate the occurrence of reactions and modifications among PGLA/ IR polymer blends and possible interactions caused by the use of organic solvent using Fourier Transformed Infrared spectroscopy (FTIR), as well as investigate about the influence of IR proportion over mechanical properties and find a correlation between PLGA and IR amounts, achieving a blend with, at least, partial miscibility
The functional groups presented in the FTIR of the different blend compositions match the molecular structures of the polymers used
Summary
The use of biologically derived polymers of other polymers into the material[1]. A brief study about (biomacromolecules) is an important component for the compatibility between PLLA and IR has already been economic development. A new class of renewable, developed in the early 2000’s, but preliminary results biodegradable, and biocompatible materials occurs indicating a total immiscibility of both polymers in a through the transformation of forest and raw agricultural blend lead the project to its discontinuity[10]. (lactic-co-glycolic acid) (PLGA) is the main idea of blending in order to reduce PLGA one of the most common biodegradable polymers. It is brittleness seems very attractive, especially achieving a copolymer of aliphatic esters, which has been used this property with the help of a polymer already applied largely as an implant that dissolves and is absorbed by on biomaterials research field
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