Analysis of plasma n-terminal pro-brain natriuretic peptide levels and its influencing factors of patients with metabolic syndrome

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Objective To analyze influence factors of the level of plasma n-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with metabolic syndrome. Methods Two hundred cases patients with the metabolic syndrome in KaiLuan General Hospital from April 2012 to April 2015 were randomly selected as the observation group, and 200 cases non-metabolic syndrome patients were randomly selected as the control group.The plasma NT-proBNP levels of the two groups were compared.Pearson correlation analysis and multiple linear regression analysis test were used to analyze the influence factors of the level of plasma NT-proBNP in patients with metabolic syndrome. Results The level of plasma NT-proBNP of the observation group and the control group were (79.23±20.16) pg/L and (102.25±27.26) pg/L respectively, the observation group was significantly lower than the control group, and the difference had statistical significance(t=4.154, P<0.05). The pearson correlation analysis showed that in observation group the plasma NT-proBNP level were positively correlated with the age, Cr, UA, aortic root diameter(AOD), left ventricular mass(LVM), left atrium diameter(LAD), left ventricular end-diastolic diamete (LVIDd), end-diastolic wall thickness after(LVPWd)(r=0.376, 0.467, 0.167, 0.237, 0.392, 0.484, 0.374, 0.234; P<0.05), and negatively correlated with BMI, TG, TC, LDL-C, Hb and left ventricular ejection fraction(LVEF)(r=-0.167, -0.253, -0.187, -0.342, -0.354, -0.563; P<0.05). The multivariate Logistic regression analysis showed that in observation group, age(OR=1.236, 95%CI 1.072-2.726, P<0.05), BMI(OR=2.256, 95%CI 1.346-2.983, P<0.05), SBP(OR=1.687, 95%CI 1.183-3.209, P<0.05), DBP(OR=1.125, 95%CI 1.052-2.037, P<0.05), FPG(OR=1.887, 95%CI 1.495-3.494, P<0.05), TG(OR=1.504, 95%CI 1.256-2.609, P<0.05), LVMI(OR=1.983, 95%CI 1.363-2.574, P<0.05) and LVEF(OR=1.485, 95%CI 1.147-2.485, P<0.05) were independent factors affecting the level of plasma NT-proBNP. Conclusion The level of plasma NT-proBNP in patients with metabolic syndrome is significantly lower than the patients without metabolic syndrome, the reason may be related to the increase in body mass index. Key words: Metabolic syndrome; N-terminal pro-brain natriuretic peptide; Factors