Analysis of photothermal coupling of titanium nitride nanorods applied to near-infrared photothermal therapy

Abstract

Titanium nitride (TiN) serves as an ideal reagent for photothermal therapy due to its cost-effectiveness, stability, and biocompatibility. This study investigates the optical and thermal properties of TiN nanoparticles in the near-infrared (NIR) region. Specifically, we employ the COMSOL Multiphysics software to solve Maxwell's equations using a finite element method, enabling us to investigate the photothermal characteristics of individual TiN nanorods. To ensure accurate photothermal coupling calculations, we utilize the Fourier steady-state heat conduction equation. The results demonstrate that the nanorod photothermal properties exhibit significantly enhanced effects when the incident light is polarized along the long axis of the rod, while the thermal properties of the nanorods are primarily influenced by their optical absorption efficiency. The tunability investigation of the nanorods demonstrates that an increase in aspect ratio (AR) results in a red-shift of the absorption peaks. Concurrently, there is an expansion in the bandwidth corresponding to the absorption peak, accompanied by an augmentation in its peak value. It is evident that at AR = 5, the TiN nanorods exhibit enhanced photothermal properties in the NIR region, resulting in a temperature increase of 43 K in the surrounding medium through efficient heat transfer. Consequently, this accomplishment enables achieving the desired temperature range for effective photothermal therapy. The significance of this study lies in providing a valuable reference and theoretical guidance for exploring the utilization of TiN nanorods in photothermal therapy, with a specific focus on attaining a more precise understanding of temperature elevation and distribution during the treatment process.