Abstract
AbstractThe feasibility of using supercritical fluid chromatography (SFC) for analysis of polar and/or ionic analytes of interest to the pharmaceutical industry is described. Specifically, the analyses of cyclopsporin (a cyclic undecapeptide), several ionophores, and a group of fat‐soluble vitamins are illustrated. The separation of group of fat‐soluble vitamins is evaluated on two bonded stationary phases, DB‐5 (95% dimethyl‐5%‐diphenylpolysiloxane) and DB‐WAX (Carbowax 20M type, “bonded”). Lastly, a new restrictor technology known as a converging‐diverging restrictor is described.
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