Abstract
The distribution of pesticide by-product in tissues of wistar rats were analyzed using high pressure liquid chromatography. The limit of detection of the HPLC was 0.1 µg. Results show bioaccumulation factor of pesticide “Raid®” in lipid, up to three times that of the feed at the first concentration and gradually decreased as the concentration increased in the muscle > (0.7), brain > (0.5) and liver > (0.3) as indicated in the text. At higher concentration of 961 µg/g, bioaccumulation factor decreased in the lipid to 1.2 and 0.6 in the muscle, 0.03 in the brain and 0.08 in the liver respectively. High Pressure Liquid Chromatography (HPLC) analysis of raid extract suggests the presence of micprothrin and palethrin. The implications are numerous, but simply put that accidental ingestion of chlorinated hydrocarbon as in “Raid®” may involve convulsions, collapse and coma after only brief excitation and ataxia at the onset.
Highlights
Pesticides have been used to boost food production to a considerable extent and to control vectors of disease [1]
Results show bioaccumulation factor of pesticide “Raid®” in lipid, up to three times that of the feed at the first concentration and gradually decreased as the concentration increased in the muscle > (0.7), brain > (0.5) and liver > (0.3) as indicated in the text
At higher concentration of 961 μg/g, bioaccumulation factor decreased in the lipid to 1.2 and 0.6 in the muscle, 0.03 in the brain and 0.08 in the liver respectively
Summary
Pesticides have been used to boost food production to a considerable extent and to control vectors of disease [1]. The chronic effects of pesticides from food intake on human health are not well defined, but there is increasing evidence of carcinogenetic [2], teratogenic [3] and genetotoxic [4], as well as disruption of hormonal functions [5]. Analysis of these pesticides and their residues had in the past aided objective re-evaluation and reassessment of these substances on a benefit-risk analysis basis and their subsequent withdrawal from use when found to be hazardous to human health and the environment. In the light of the above, and in view of pesticide related adverse reactions, the study, presents chromatographic and absorption spectra from a common pesticide Raid® in tissue of rat as it affects basal metabolism using high pressure liquid chromatograph
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