Analysis of peripheral blood parameters for the diagnosis of inflammatory activity in rheumatoid arthritis

Abstract

Currently, it is considered generally accepted to assess the activity of inflammation in rheumatoid arthritis (RA) according to the disease activity index (DAS28), which requires computer technology. However, there have been reports that inflammatory activity in autoimmune diseases can be diagnosed with peripheral blood counts.Aim. To clarify the possibility of using peripheral blood parameters for the diagnosis of inflammatory activity in rheumatoid arthritis.Material and methods. The study included 100 patients with RA who were consecutively hospitalized in the first quarter of 2021 due to an exacerbation. The control group consisted of 59 healthy donors. When patients were admitted to the clinic, along with standard clinical, laboratory and radiological parameters, the neutrophil-tolymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios were determined.Results. Correlation analysis of the studied clinical and laboratory parameters of the inflammatory activity of RA patients using the Pearson method showed that the NLR indicator, in contrast to the PLR, was statistically significant (p<0.05) correlated with the swollen joint count (r=0.236), the values of C-reactive protein (CRP) (r=0.448), erythrocyte sedimentation rate (ESR) (r=0.274) and DAS28-ESR (r=0.274). ROC-analysis of the sensitivity and specificity of the NLR value in relation to the CRP and ESR indicators confirmed an acceptable level of sensitivity and specificity in assessing the inflammatory activity of RA.Conclusions. The NLR index, calculated from the data of the analysis of peripheral blood, can be used in clinical practice as an objective and accessible marker of the inflammatory activity of RA.