Analysis of pattern and early changes of organs amongst admitted Patients in Intensive Care Unit and their relation to outcome

Abstract

Objective: To assess the patterns and changes of organs amongst patients admitted in intensive care unit and to analyze the outcome of respective disease. Study Design: A prospective observational study. Place and Duration: Intensive Care Unit of Bakhtawar Amin Hospital, Multan from 1st March 2022- 31st March 2023. Methodology: A total of 200 patients admitted to the ICU were included in the study for analysis. Demographic information and comorbidities data were collected for each patient on admission. Patients were tested daily for infection and antibiotics were given. Sequential organ failure assessment score (SOFA) was used to assess organ function on admission and then every day after admission. We divided patients into 3 categories: patients who never developed sepsis, patients with sepsis development within 48 hours of admittance, and patients with sepsis development 48 hours after ICU admission. Results: The Simplified Acute Physiology score (SAPS) and SOFA score at admission were 34.5 ± 15.2 and 4.5 ± 2.8 respectively. The overall mortality in ICU was 15% and in-hospital mortality was 20%. During the ICU stay, 80 patients developed sepsis, among which 60 patients (30%) developed it within 48 hours and 20 patients (10%) after the 48 hours of ICU admission. Overall, in-hospital and ICU mortality was lower in patients without sepsis than those with sepsis (p<0.001). Conclusion: Early changes of organ failure is strongly associated with disease prognosis and outcome. Keywords: Intensive Care Unit, Multiple Organ Failure, Sepsis, Simplified Acute Physiology Score, Sequential Organ Failure Assessment Score. How to Cite This: Ather MM, Mukhtar S, Gardazi A, Rasheeq T, Tahir M, Muzammil M. Analysis of pattern and early changes of organs amongst admitted patients in Intensive Care Unit and their relation to outcome. Isra Med J. 2023; 15(1):25-29. DOI: https://doi.org/10.55282/imj.oa1366. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited