Abstract
Ionizing radiation with low-linear energy transfer generates reactive oxygen species (ROS) or free radicals such as superoxide, hydrogen peroxide, and hydroxyl radicals by indirect action of energy on water molecules and simultaneously generating doublestrand breaks (DSBs), which are known to be lethal, by direct action on DNA itself, with sequence apoptosis or stress-related responses [1,2].
Highlights
Ionizing radiation with low-linear energy transfer generates reactive oxygen species (ROS) or free radicals such as superoxide, hydrogen peroxide, and hydroxyl radicals by indirect action of energy on water molecules and simultaneously generating doublestrand breaks (DSBs), which are known to be lethal, by direct action on DNA itself, with sequence apoptosis or stress-related responses [1,2]
A similar trend was observed in the group exposed to 2 Gy irradiation; no significant decrease was observed in the number of Bone Marrow Mononuclear Cells (BM-MNCs) in the mice exposed to 0.5 Gy irradiation
The levels of oxidative stress generated in murine plasma were evaluated by measuring the free radical metabolite and antioxidant activity levels
Summary
Ionizing radiation with low-linear energy transfer generates reactive oxygen species (ROS) or free radicals such as superoxide, hydrogen peroxide, and hydroxyl radicals by indirect action of energy on water molecules and simultaneously generating doublestrand breaks (DSBs), which are known to be lethal, by direct action on DNA itself, with sequence apoptosis or stress-related responses [1,2]. Reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) are used to evaluate the antioxidant activity and degree of oxidation in organisms. The level of hydroperoxide, which is a chemical oxidant species belonging to the active oxygen metabolites, can be measured using the d-ROMs test. Various levels of antioxidants such, as ascorbic acid, uric acid and bilirubin, can be measured using the BAP test [5]. These tests are known for the rapidity, simplicity and high reproducibility of their methodologies. Since it is important to determine the oxidative conditions of individuals exposed to ionizing radiation, the aim of the present study was to use the d-ROMs and BAP tests to assess oxidative stress in irradiated mice
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biomedical Journal of Scientific & Technical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
