Abstract
BackgroundOvarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies. In recent years, infrared (IR) spectroscopy has gained attention as a simple and inexpensive method for the biomedical study of several diseases. In the present study infrared spectra of normal and malignant ovarian tissues were recorded in the 650 cm-1 to 4000 cm-1 region.MethodsPost surgical tissue samples were taken from the normal and tumor sections of the tissue. Fourier Transform Infrared (FTIR) data on twelve cases of ovarian cancer with different grades of malignancy from patients of different age groups were analyzed.ResultsSignificant spectral differences between the normal and the ovarian cancerous tissues were observed. In particular changes in frequency and intensity in the spectral region of protein, nucleic acid and lipid vibrational modes were observed. It was evident that the sample-to-sample or patient-to-patient variations were small and the spectral differences between normal and diseased tissues were reproducible.ConclusionThe measured spectroscopic features, which are the spectroscopic fingerprints of the tissues, provided the important differentiating information about the malignant and normal tissues. The findings of this study demonstrate the possible use of infrared spectroscopy in differentiating normal and malignant ovarian tissues.
Highlights
Ovarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies
As most of the phosphodiester groups in biological tissues are found in nucleic acids [34,35], these two bands are associated to the nucleic acid content of a cell
Malignant tissue shows a strong peak at 1069 cm-1, which is present as a broad peak of lesser intensity at 1078 cm-1 in the spectrum of normal tissue
Summary
Ovarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies. In the present study infrared spectra of normal and malignant ovarian tissues were recorded in the 650 cm-1 to 4000 cm-1 region. Ovarian cancer is one of the leading causes of cancerrelated deaths among women worldwide. In India, the Indian Council of Medical Research reports the incidence rate of ovarian cancer as 4.2 per 100,000 women [1]. A woman has a lifetime risk of ovarian cancer of around 1.5%, which makes it the second most common gynecologic malignancy [2]. Ovarian cancer usually occurs in women over the age of 50 years, but it can affect younger women. Two types of ovarian cancers are found based on the cell types.
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